2007 Apr;56(4):1345-54. However, it seems that studying experimental pain alone does not supply the complete picture, and that PET scanning patients experiencing different types of clinical pain can reveal subtle changes in brain activity. Each patient plus rated their perceived pain intensity and unpleasantness on 0 - 100 rating scales at 10 minute intervals.

Dr Kulkarni said: “We knew from our previous neuro-imaging studies that experimentally-induced pain is processed in at least two brain networks, collectively known as the ‘pain matrix.’ The ‘medial pain system’ processes the emotional aspects such as pain’s unpleasantness, while the ‘lateral pain system’ processes the pain’s intensity, location and duration.

“We wanted to see whether the same applied to the clinical pain suffered by public with conditions like arthritis, as no direct comparisons of experimental and clinical pain had been undertaken in the same group of patients.”

Six female and six male patients with osteoarthritis of the knee underwent PET brain-scanning during three different pain states: arthritic knee pain, experimental knee pain (when no arthritic pain was present) and a pain-free state.
Arthritic pain is processed in brain areas concerned with emotions and fear.
Arthritis Rheum.

In a study published in ‘Arthritis and Rheumatism’ that week, they compare the brain areas involved in processing arthritic and experimental pain in a group of patients with osteoarthritis.

The study was funded by the Arthritis Research Campaign

---

Kulkarni B, Bentley DE, Elliott R, Julyan PJ, Boger E, et al.   [Abstract]

A team led by Dr Bhavna Kulkarni has captured the first images of how the brain processes arthritis pain, using positron emission tomography (PET) scanners based at the Christie Hospital. “But, although both activated both the medial and lateral pain systems, arthritic pain prompted increased activity in the cingulate cortex, thalamus and amygdale within the medial system - the areas concerned with processing fear, emotions and aversive conditioning.

“This suggests that arthritic pain has more emotional salience than experimental pain for these patients, which is consistent with the unpleasantness scores they themselves gave.

“We thought that arthritic and acute experimental pain would be processed within the same areas of the pain matrix,” Dr Kulkarni continued.

Researchers at The University of Manchester have discovered that arthritis pain, unlike that induced as part of an experiment, is processed in the parts of the brain concerned with emotions and fear. The increased activity in the areas associated with aversive conditioning, reward and fear, which are less commonly activated during experimental pain, suggests they might be processing fear of further injury and disability associated with the arthritic pain.”

Project supervisor Professor Anthony Jones, whose Human Pain Research Group is based at Salford Royal NHS Foundation Trust, said: “The finding that both experimental and arthritic pain activate the medial and lateral pain systems suggests that there isn’t a different brain network for processing arthritic pain, and we are therefore justified in using experimental pain to investigate the generalized mechanisms of pain perception.

Original post by Anxiety Insights

Share and Enjoy: These icons link to social bookmarking sites where readers can share and discover new web pages.

• 
• 
• 
• 
• 
• 
•