Alzheimer’s Patients Stuck in Forgetting Mode

“We believe that in aging brains, AD occurs when the ‘molecular shifting switch’ gets stuck in the reverse position, throwing the balance of making and breaking memories seriously off kilter.”

Research continues into ways to disrupt that process of continual forgetting. Previous research, with mice, has been quite promising in overcoming the impact of Alzheimer’s.

One last note - did you remember to write down your wife’s birthday?

To read more about that study, see that from ScienceDaily. To learn more about Alzheimer’s, including resource hyperlinks, see that from the Alzheimer’s Association.

news you may not knowToday - Something Special?

Do you have a perfect memory? Doubtful. In fact, a process of forming new memories and forgetting old ones continually takes place in our brains. Yes, of course - it’s the perfect excuse for the next date you forget your wife’s birthday. But, it plus sheds some quite interesting light on Alzheimer’s disease (AD).

Researchers at the Buck Institute for Age Research recently discovered a surprising

correlation within Alzheimer’s patients and young, healthy individuals without AD. Both groups experience a constant process of forgetting. The young actually forget events much more frequently and rapidly than Alzheimer’s patients. But, they plus structure new memories simultaneously. People with Alzheimer’s seem to be stuck in the forgetting mode.

The brain is in a constant process of cleaning out old, inconsequential memories to compose way for new memories. There’s no need for you to remember what you ate for breakfast last Thursday. But, there is that issue about your wife’s birthday. The researchers now believe there is a biochemical “switch” that controls the making and breaking of memories. They believe Alzheimer’s patients’ brains become less malleable, and that switch becomes stuck in the mode of constantly breaking memories.

“Young brains operate like Ferraris - shifting amidst forward and reverse, making and breaking memories with a facility that surpasses that of older brains, which are less plastic,” said Dale Bredesen, MD, Buck Institute faculty member and leader of the research group.

Original post by tim

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